We are committed to promote reproducibility and transparency of research findings. For each of our modeling studies, we usually publish the source model codes as a Supplementary Material of the manuscript. We also upload the source mode code files to GitHub before we submit the manuscript. Please refer to the GitHub sites below for source code files of our published models.
In addition, we are dedicated to converting our PK models to web-based interfaces to facilitate applications of our models by a wider scientific community. We also convert our research data to be a web dashboard, so that other researchers can access our research findings easily. Below is a list of our PK model web interfaces and databases with direct URL links and citations.
GitHub at K-State: https://github.com/KSUICCM
GitHub at UF: https://github.com/UFPBPK
Interactive physiologically based pharmacokinetic (iPBPK) models:
1. An iPBPK model for penicillin G in beef cattle and market-age swine
Link: https://pengpbpk.shinyapps.io/pen_g/
Citation: Li M, Gehring R, Riviere JE, Lin Z. (2017). Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment. Food and Chemical Toxicology, 107:74-87.
2. An iPBPK model for flunixin in beef cattle and market-age swine
Link: https://pengpbpk.shinyapps.io/Flunixin/
Citation: Li M, Cheng YH, Chittenden JT, Baynes RE, Tell LA, Davis JL, Vickroy TW, Riviere JE, Lin Z. (2019). Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically-based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration. Archives of Toxicology, 93(7):1865-1880.
3. An iPBPK model for oxytetracycline in market-age sheep and goats
Old Link: https://iccmapp.shinyapps.io/iPBPK/
New Link: https://pbpk.shinyapps.io/OTC_App/
Citation: Riad MH, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. (2021). Development and application of an interactive physiologically based pharmacokinetic (iPBPK) model to predict oxytetracycline tissue distribution and withdrawal intervals in market-age sheep and goats. Toxicological Sciences, 183(2):253-268.
4. An iPBPK model for meloxicam in broiler chickens and laying hens
Link: https://pbpk.shinyapps.io/Meloxicam/
Citation: Yuan L, Chou WC, Richards ED, Tell LA, Baynes RE, Davis JL, Riviere JE, Lin Z. (2022). A web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens. Food and Chemical Toxicology, 168:113332.
5. An iPBPK model for penicillin G, flunixin, and florfenicol in beef cattle and swine
Link: https://pbpk.shinyapps.io/igPBPKApp/
Citation: Chou WC, Tell LA, Baynes RE, Davis JL, Maunsell FP, Riviere JE, Lin Z. (2022). An interactive generic physiologically based pharmacokinetic (igPBPK) modelling platform to predict drug withdrawal intervals in cattle and swine. Toxicological Sciences, 188(2):180-197.
6. An iPBPK model for gold nanoparticles in rats
Link: https://pbpk.shinyapps.io/NanoiPBPK/
Citation: Chou WC, Cheng YH, Riviere JE, Monteiro-Riviere NA, Kreyling WG, Lin Z. (2022). Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in rats. Particle and Fibre Toxicology, 19(1):47.
Other pharmacokinetic models:
1. Withdrawal Interval Calculator (WIC)
Link: https://wic.apps.it.ufl.edu/
Citation: Gehring R, Baynes RE, Craigmill AL, Riviere JE. (2004). Feasibility of using half-life multipliers to estimate extended withdrawal intervals following the extralabel use of drugs in food-producing animals. Journal of Food Protection, 67(3):555-60.
Physiological parameters for PBPK modeling in food animals:
Link: https://cafarad.ucdavis.edu/pbpk
Citations:
Lin Z, Li M, Wang YS, Tell LA, Baynes RE, Davis JL, Vickroy TW, Riviere JE. (2020). Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and Swine. Journal of Veterinary Pharmacology and Therapeutics, 43(5):385-420.
Wang YS, Li M, Tell LA, Baynes RE, Davis JL, Vickroy TW, Riviere JE, Lin Z. (2021). Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part II: Chicken and turkey. Journal of Veterinary Pharmacology and Therapeutics, 44(4), 423-455.
Li M, Wang YS, Elwell-Cuddy T, Baynes RE, Tell LA, Davis JL, Maunsell FP, Riviere JE, Lin Z. (2021). Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part III: Sheep and goat. Journal of Veterinary Pharmacology and Therapeutics, 44(4), 456-477.