Principle Investigator

Zhoumeng Lin

Zhoumeng Lin BMed, PhD, DABT, CPH

Associate Professor
Phone: (352) 273-6160

Dr. Zhoumeng Lin is an Associate Professor in the Department of Environmental and Global Health and a member of the Center for Environmental and Human Toxicology. He received a B.Med. in Preventive Medicine from Southern Medical University in China in 2009 and a Ph.D. in Toxicology from the University of Georgia in 2013. He completed his postdoctoral training in the Institute of Computational Comparative Medicine at Kansas State University in 2016. He was an Assistant Professor from 2016 to 2021 and then an Associate Professor from March to May 2021 at Kansas State University, prior to joining the University of Florida as an Associate Professor in May 2021.

Dr. Lin’s research is focused on the development and application of computational technologies, especially physiologically based pharmacokinetic (PBPK) modeling, to study food safety, nanoparticle and chemical risk assessment. He is a co-author of more than sixty peer-reviewed publications. His publications have received several awards, including the Society of Toxicology Biological Modeling Specialty Section Best Paper Award in 2020.

Dr. Lin teaches a graduate level course on PBPK modeling every year. He is a co-editor and a co-author of five chapters of a recently published textbook entitled “Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment”.

Dr. Lin has served as an ad hoc grant reviewer for several agencies, including USDA and NIH. He is an ad hoc member of the Science Advisory Committee on Chemicals (SACC) of US EPA. He has served as an external reviewer on several risk assessment documents on different environmental chemicals for different agencies, including EPA, CDC, and FDA. He has been a member of Society of Toxicology since 2011. He served as a Sunday Host Mentor for the Sunday Undergraduate Education Program organized by the Committee on Diversity Initiatives of Society of Toxicology from 2016 to 2017 and he was a Secretary/Treasurer of Central States Society of Toxicology (CSSOT) from 2018 to 2020. He is now the Vice President-Elect of the Biological Modeling Specialty Section (BMSS) and a Councilor of the Nanoscience and Advanced Materials Specialty Section (NAMSS) of Society of Toxicology.

  • Vice President-Elect, Biological Modeling Specialty Section
    2021-2025 · Society of Toxicology
  • Councilor, Nanoscience and Advanced Materials Specialty Section
    2021-2023 · Society of Toxicology
  • Best Paper Award of the Year 2020 (Honorable Mention)
    2021 · Biological Modeling Specialty Section, Society of Toxicology
  • Co-Editor of the textbook "Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment"
    2020 · Elsevier
  • Best Paper Award of the Year 2019
    2020 · Biological Modeling Specialty Section, Society of Toxicology
  • Secretary/Treasurer, Central States Society of Toxicology
    2018-2020 · Society of Toxicology
  • Certified in Public Health (CPH)
    National Board of Public Health Examiners (NBPHE)
  • Diplomate of the American Board of Toxicology (DABT)
    American Board of Toxicology
  • Population PK/PD Pharmacometrician (Level 1) using Phoenix NLME 8.0 and 8.1
    Certara Professional Certification
Research Summary:

Dr. Lin’s areas of expertise include Toxicology, Risk Assessment, Environmental Health, and Pharmacology. His research interest is in the development and application of computational technologies for environmental chemicals, nanoparticles and drugs in animals and humans to address research questions related to nanomedicine, animal-derived food safety assessment, and environmental chemical risk assessment. The computational technologies used in his research include physiologically based pharmacokinetic (PBPK), pharmacokinetics/pharmacodynamics (PK/PD), toxicogenomics, machine learning, and artificial intelligence (AI) approaches. The long-term goal of his research is to develop AI-assisted computational approaches to support decision-making in human health, animal health, and environmental health (i.e., one health approach).

Currently, there are three specific projects in his laboratory. The first project is to develop PBPK models for drugs in food-producing animals, such as cattle, swine, sheep, goats, chickens, turkeys, and fish. The second project is to develop AI-assisted PBPK models for nanoparticles in both healthy and tumor-bearing animals. The third project is develop PBPK models for environmental chemicals, such as per- and polyfluoroalkyl substances (PFAS) in animals and humans of different life stages.

  • Sep 2021 ACTIVE
    FARAD, aka Food Animal Residue Avoidance Databank
    UNIV OF CALIFORNIA DAVIS · Principal Investigator
  • Sep 2021 ACTIVE
    2021 FARAD
  • Sep 2021 ACTIVE
    Development of a web-based predictive model of nanoparticle delivery to tumors by integrating physiologically-based pharmacokinetic modeling with artificial intelligence
    NATL INST OF HLTH NIBIB · Principal Investigator
  • Aug 2021 ACTIVE
    Physiologically based pharmacokinetic modeling and analysis of administration route-dependent tissue distribution of gold nanoparticles
    NATL INST OF HLTH NIBIB · Principal Investigator
  • 2013
    Doctor of Philosophy (PhD) in Toxicology
    University of Georgia
  • 2009
    Bachelor of Medicine (BMed) in Preventive Medicine
    Southern Medical University, Guangzhou, China

Lab Members

Wei-Chun Chou

Wei-Chun Chou

Research Assistant Professor
Phone: (352) 273-9188
Long Yuan

Long Yuan PHD

Postdoctoral Fellow
Phone: (513) 720-9627
Qiran Chen

Qiran Chen PHD

Postdoctoral Fellow
Phone: (352) 273-9188

Lab Alumni

Postdoctoral Fellows:

  • Miao Li, 2016.08-2019.08, First Position: Visiting Scientist, National Center for Toxicological Research (NCTR), US Food and Drug Administration (FDA), Jefferson, AR
  • Yi-Hsien Cheng, 2016.12-2020.12, First Position: Pharmacologist/Biopharmaceutical Scientist – Investigator III, US Food and Drug Administration (FDA), Silver Spring, MD
  • Wei-Chun Chou, 2018.08-2021.05, First Position: Research Assistant Professor, Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida
  • Md Mahbubul Huq Riad, 2020.09-2021.10, First Position: Senior Quantitative Systems Pharmacologist I, AbbVie, North Chicago, IL

Undergraduate Students:

  • Trevor Elwell-Cuddy, 2016.08-2018.05, First Position: PBPK modeler in the Wright–Patterson Air Force Base
  • Sichao Mao, 2018.01-2018.06, First Position: DVM student at Iowa State University
  • Yilei Zheng, 2018.01-2018.06, First Position: DVM student at University of Minnesota
  • Yu-Shin Wang, 2018.06-2020.11, First Position: DVM student at Kansas State University
  • Jake Willson, 2019.10-2020.05, First Position: Software Engineer, Cerner, Kansas City, MO

Visiting Students/Scholars:

  • Dongping Zeng, 2016.10-2017.10, First Position: Associate Professor, South China Agricultural University, Guangzhou
  • Paula Solar Oliver, 2017.02-2017.03, First Position: Executive Director at the Chilean Council of Foresight and Strategy
  • Ning Xu, 2018.12-2019.12, First Position: Assistant Researcher, Chinese Academy of Fishery Sciences, Wuhan
  • Yi-Jun Lin, 2019.07-2020.02, First Position: Assistant Professor, National Yang-Ming University, Taiwan