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UF Health University of Florida
Dr. Zhoumeng Lin's Lab College of Public Health and Health Professions

Team

Principle Investigator

Zhoumeng Lin

Zhoumeng Lin BMed, PhD, DABT, CPH, ERT

Associate Professor
Department: Department of Environmental and Global Health
Phone: (352) 273-6160
Email: linzhoumeng@ufl.edu
CV: View Curriculum Vitae:
Mailing Address:
PO Box 100188
 GAINESVILLE FL 32610
Physical Address:
1225 CENTER DR
 GAINESVILLE FL 32610

Dr. Zhoumeng Lin is an Associate Professor in the Department of Environmental and Global Health at College of Public Health and Health Professions at the University of Florida. He has joint appointments in Department of Pharmaceutics at College of Pharmacy and Department of Physiological Sciences in College of Veterinary Medicine. He is a member of the Center for Environmental and Human Toxicology (CEHT) and the Center for Pharmacometrics and Systems Pharmacology (CPSP). He received a B.Med. in Preventive Medicine from Southern Medical University in China in 2009 and a Ph.D. in Toxicology from the University of Georgia in 2013. He completed his postdoctoral training in the Institute of Computational Comparative Medicine at Kansas State University in 2016. He was an Assistant Professor from 2016 to 2021 and then an Associate Professor from March to May 2021 at Kansas State University, prior to joining the University of Florida as an Associate Professor in May 2021.

Dr. Lin’s research is focused on the development and application of computational technologies, especially physiologically based pharmacokinetic (PBPK) modeling, machine learning, and artificial intelligence approaches, to study nanomedicine, food safety, nanoparticle and chemical risk assessment. He is a co-author of more than eighty peer-reviewed publications. His publications have received several awards, including the Society of Toxicology Biological Modeling Specialty Section Best Paper Award in 2020 and 2022.

Dr. Lin teaches a graduate level course on PBPK modeling every year. He is a co-editor and a co-author of five chapters of the textbook entitled “Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment”.

Dr. Lin has served as an ad hoc grant reviewer for several agencies, including USDA and NIH. He is an ad hoc member of the Science Advisory Committee on Chemicals (SACC) of US EPA. He has served as an external reviewer on several risk assessment documents on different environmental chemicals for different agencies, including EPA, CDC, and FDA. He has been a member of Society of Toxicology since 2011. He served as a Sunday Host Mentor for the Sunday Undergraduate Education Program organized by the Committee on Diversity Initiatives of Society of Toxicology from 2016 to 2017 and he was a Secretary/Treasurer of Central States Society of Toxicology (CSSOT) from 2018 to 2020. He is now the Vice President of the Biological Modeling Specialty Section (BMSS) and a Councilor of the Nanoscience and Advanced Materials Specialty Section (NAMSS) of Society of Toxicology.

Accomplishments:
  • Best Paper Award of the Year 2023
    2024 · Biological Modeling Specialty Section, Society of Toxicology
  • Dean's Citation Paper Award
    2023 · UF PHHP
  • Best Paper Award of the Year 2022
    2023 · Nanoscience and Advanced Materials Specialty Section, Society of Toxicology
  • World's Top 2% Scientists in 2021
    2022 · Stanford University (https://elsevier.digitalcommonsdata.com/datasets/btchxktzyw)
  • JOINN Biomere Outstanding Young Toxicologist Award
    2022 · American Association of Chinese in Toxicology (AACT) Special Interest Group, Society of Toxicology
  • Best Paper Demonstrating an Application of Risk Assessment Award of the Year 2021
    2022 · Risk Assessment Specialty Section, Society of Toxicology
  • Best Paper Award of the Year 2021
    2022 · Biological Modeling Specialty Section, Society of Toxicology
  • Vice President-Elect, Biological Modeling Specialty Section
    2021-2025 · Society of Toxicology
  • Councilor, Nanoscience and Advanced Materials Specialty Section
    2021-2023 · Society of Toxicology
  • World’s Top 2% Scientists in 2020
    2021 · Stanford University (https://elsevier.digitalcommonsdata.com/datasets/btchxktzyw/3)
  • Best Paper Award of the Year 2020 (Honorable Mention)
    2021 · Biological Modeling Specialty Section, Society of Toxicology
  • Co-Editor of the textbook "Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment"
    2020 · Elsevier
  • Best Paper Award of the Year 2019
    2020 · Biological Modeling Specialty Section, Society of Toxicology
  • Secretary/Treasurer, Central States Society of Toxicology
    2018-2020 · Society of Toxicology
Certifications:
  • Certified in Public Health (CPH)
    National Board of Public Health Examiners (NBPHE)
  • Diplomate of the American Board of Toxicology (DABT)
    American Board of Toxicology
  • European Registered Toxicologist (ERT)
    UK Register of Toxicologists
  • Population PK/PD Pharmacometrician (Level 1) using Phoenix NLME 8.0 and 8.1
    Certara Professional Certification
Research Summary:

Dr. Lin’s areas of expertise include Toxicology, Risk Assessment, Environmental Health, and Pharmacology. His research interest is in the development and application of computational technologies for environmental chemicals, nanoparticles and drugs in animals and humans to address research questions related to nanomedicine, animal-derived food safety assessment, and environmental chemical risk assessment. The computational technologies used in his research include physiologically based pharmacokinetic (PBPK), pharmacokinetics/pharmacodynamics (PK/PD), toxicogenomics, machine learning, and artificial intelligence (AI) approaches. The long-term goal of his research is to develop AI-assisted computational approaches to support decision-making in human health, animal health, and environmental health (i.e., one health approach).

Currently, there are three specific projects in his laboratory. The first project is to develop PBPK models for drugs in food-producing animals, such as cattle, swine, sheep, goats, chickens, turkeys, and fish. The second project is to develop AI-assisted PBPK models for nanoparticles in both healthy and tumor-bearing animals. The third project is develop PBPK models for environmental chemicals, such as per- and polyfluoroalkyl substances (PFAS) in animals and humans of different life stages.

Publications:
Grants:
  • Sep 2024 ACTIVE
    2024 FARAD – Food Animal Residue Avoidance Database Program – UF Component
    US DEPT OF AG NATL INST OF FOOD AND AG · Co-Project Director/Principal Investigator
  • May 2024 ACTIVE
    Computational Modeling on the Interaction of Nanomedicine with Protein Corona and Its Impact on Tumor Delivery Efficiency
    UNIV OF CALIFORNIA RIVERSIDE · Principal Investigator
  • Mar 2024 ACTIVE
    Estimation of Withdrawal Intervals for Selected Drugs Administered to Pigs Exported to Foreign Markets with Different MRLs
    NORTH CAROLINA STATE UNIV · Principal Investigator
  • Sep 2023 ACTIVE
    2023 FARAD – Food Animal Residue Avoidance Database Program – UF Component
    US DEPT OF AG NATL INST OF FOOD AND AG · Co-Project Director/Principal Investigator
  • Sep 2022 ACTIVE
    2022 FARAD – UF Component
    US DEPT OF AG NATL INST OF FOOD AND AG · Co-Project Director/Principal Investigator
  • Sep 2021 – Aug 2022
    FARAD, aka Food Animal Residue Avoidance Databank
    UNIV OF CALIFORNIA DAVIS · Principal Investigator
  • Sep 2021 – Feb 2023
    Childrens Hospital of Philadelphia (CHOP) Project
    CHILDRENS HOSP PHILADELPHIA · Principal Investigator
  • Sep 2021 – Aug 2024
    2021 FARAD
    US DEPT OF AG NATL INST OF FOOD AND AG · Co-Project Director/Principal Investigator
  • Sep 2021 ACTIVE
    Development of a web-based predictive model of nanoparticle delivery to tumors by integrating physiologically-based pharmacokinetic modeling with artificial intelligence
    NATL INST OF HLTH NIBIB · Principal Investigator
  • Aug 2021 – Sep 2021
    Evaluation of pharmacokinetic profiles based on multiple parameters: TARGETED NANO-CHEMOTHERAPEUTICS FOR CA
    UNIV OF MISSOURI · Principal Investigator
  • Aug 2021 – Jun 2022
    Physiologically based pharmacokinetic modeling and analysis of administration route-dependent tissue distribution of gold nanoparticles
    NATL INST OF HLTH NIBIB · Principal Investigator
  • May 2021 – Aug 2023
    Food Animal Residue Avoidance Databank (FARAD)
    KANSAS STATE UNIVERSITY · Principal Investigator
  • May 2021 – Aug 2022
    Food Animal Residue Avoidance Databank (FARAD) 2019
    KANSAS STATE UNIVERSITY · Principal Investigator
Education:
  • 2013
    Doctor of Philosophy (PhD) in Toxicology
    University of Georgia
  • 2009
    Bachelor of Medicine (BMed) in Preventive Medicine
    Southern Medical University, Guangzhou, China
Full Profile

Lab Members

Qiran Chen
Department: Department of Environmental and Global Health

Qiran Chen PHD

Postdoctoral Fellow
Phone: (352) 273-9188
Xue Wu
Department: Department of Environmental and Global Health

Xue Wu

GRADUATE AST-R
Phone: (352) 273-9188
Chi-Yun Chen
Department: Department of Environmental and Global Health

Chi-Yun Chen

Post Doc Associate
Phone: (352) 273-9188
Pei-Yu Wu
Department: Department of Environmental and Global Health

Pei-Yu Wu

GRADUATE AST-R
Phone: (352) 273-9188
Zhicheng Zhang
Department: Department of Environmental and Global Health

Zhicheng Zhang

GRADUATE AST-R
Phone: (352) 273-9188
Kun Mi
Department: Department of Environmental and Global Health

Kun Mi

Post Doc Associate
Phone: (352) 642-6589
Xinyue Chen
Department: Department of Environmental and Global Health

Xinyue Chen

GRADUATE AST-R
Phone: (352) 273-5680

PhD Student:

  • Xue Wu, 2022.08-present, PhD in Public Health with a Concentration in Environmental Health
  • Pei-Yu Wu, 2023.01-present, PhD in Public Health with a Concentration in Environmental Health
  • Zhicheng Zhang, 2023.08-present, PhD in Public Health with a Concentration in Environmental Health
  • Xinyue Chen, 2024.08-present, PhD in Public Health with a Concentration in Environmental Health

Lab Alumni

Postdoctoral Fellows:

  • Miao Li, 2016.08-2019.08, First Position: Visiting Scientist, National Center for Toxicological Research (NCTR), US Food and Drug Administration (FDA), Jefferson, AR
  • Yi-Hsien Cheng, 2016.12-2020.12, First Position: Pharmacologist/Biopharmaceutical Scientist – Investigator III, US Food and Drug Administration (FDA), Silver Spring, MD
  • Wei-Chun Chou, 2018.08-2021.05 (Postdoctoral Fellow), 2021.05-2023.12 (Research Assistant Professor), First Position: Assistant Professor, Department of Environmental Sciences, University of California, Riverside
  • Md Mahbubul Huq Riad, 2020.09-2021.10, First Position: Senior Quantitative Systems Pharmacologist I, AbbVie, North Chicago, IL
  • Long Yuan, 2020.09-2022.08, First Position: Senior Scientist in Pharmacometrics, Neurocrine Biosciences, Inc., San Diego, CA
  • Malek Hussein Hajjawi, 2022.10-2024.01, First Position: Clinical Pharmacology Fellow, Indiana University, Bloomington, IN

Undergraduate Students:

  • Trevor Elwell-Cuddy, 2016.08-2018.05, First Position: PBPK modeler in the Wright–Patterson Air Force Base
  • Sichao Mao, 2018.01-2018.06, First Position: DVM student at Iowa State University
  • Yilei Zheng, 2018.01-2018.06, First Position: DVM student at University of Minnesota
  • Yu-Shin Wang, 2018.06-2020.11, First Position: DVM student at Kansas State University
  • Jake Willson, 2019.10-2020.05, First Position: Software Engineer, Cerner, Kansas City, MO
  • Ethan Cecil, 2023.11-2024.05, First Position: Undergraduate Student, University of Florida, Gainesville, FL

Visiting Students/Scholars:

  • Dongping Zeng, 2016.10-2017.10, First Position: Associate Professor, South China Agricultural University, Guangzhou
  • Paula Solar Oliver, 2017.02-2017.03, First Position: Executive Director at the Chilean Council of Foresight and Strategy
  • Ning Xu, 2018.12-2019.12, First Position: Assistant Researcher, Chinese Academy of Fishery Sciences, Wuhan
  • Yi-Jun Lin, 2019.07-2020.02, First Position: Assistant Professor, National Yang-Ming University, Taiwan
  • Guanyu (Gabriel) Tao, 2021.07-2021.08 (summer intern), First Position: Senior Scientist, ADME & Discovery Toxicology Group, Merck, Boston, MA